> General, Genetics > Deadly Skin Cancer Metastasis May Be Halted Following Research Breakthrough
More than 1 million cases of skin cancer are diagnosed each year in the U.S. and melanoma is the deadliest form. Recently scientists have?eliminated metastasis, the spread of cancer?from the original tumor to other parts of the body, in melanoma by inhibiting a protein known as melanoma differentiation associated gene-9 (mda-9)/syntenin. Paul B Fisher, M.Ph., Ph.D., Thelma Newmeyer Corman Endowed Chair in Cancer Research and his colleagues have found that Raf kinase inhibitor protein interacted with and suppressed mda-9/syntenin. Before now, Fisher had originally cloned mda-9/syntenin in his laboratory, and in previous studies it interacted with another protein, c-Src, that lead to increased metastasis.??In addition to providing a new target for future therapies, there is potential for using these two genes as biomarkers for monitoring melanoma development and progression,? says Fisher.?Now that the researchers have demonstrated the ability of RKIP to inhibit mda-9/syntenin-mediated metastasis, they are focusing their attention on developing small molecules imitating RKIP that could be used as new treatments for melanoma.
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